Enhance immune protection
Boost metabolism
Keep the organ systems in balance
Increase nutrient absorption
Level up antioxidant ability
GMIPlUS® IMMUNITY BALANCING gather 11 kinds of healthy ingredients to provide comprehensive protection of body organs, improve physiological functions, increase nutrient absorption, balance immunity, and then rebuild physical fitness, build an armor-like defense for body functions, and block aging and poor diet And the harm caused by lifestyle and environmental pollution.
11 exclusive professional-grade ingredients
GMIPLUS® Immuno-Protein
Sea Buckthorn Extract
Bilberry Extract
CS-4™ Cordyceps sinensis Mycelium
Astragalus Extract
Algae Oil Powder
Aronia Berry Extract
Turmeric Extract
Brazilian Mushroom Extract
Glutathione
30 Billion Probiotics
IMMUNITY BALANCING
Professional Ingredients Description
Professional Precision medicine formulation opens the gate to improving immunity and body functions.
GMIPLUS® Immuno Protein
GMIPLUS® is an immune-modulatory protein derived from Ganoderma microsporum. It is cultivated by S. cerevisiae through sophisticated biological genetic medicine process. It has multiple immune modulation and anti-cancers effects. Clinical evidences had shown it's immunologic balancing and enhance metabolism, in further it can inhibit multiple cancers stem cells.
GMIPLUS® Immuno Protein
8 Major product features
The National Institutes of Health (NIH) has confirmed through experiments that GMIPLUS® has an inhibitory effect and killing effect on a variety of cancer cell lines, and has obtained a medical certificate of "treatment of cancer cell invasion and migration". Medical research of publish shown that GMIPLUS® can be combined use with anticancer drugs -Cisplatin, to reduce the resistance of cancer stem cells.
GMIPLUS® Immuno Protein
mainefficacy and research patents
- Obtained medicinal evidence for the treatment of cancer cell invasion and metastasis: NIH experi ments in the United States have found inhibitory and killing effects on a variety of cancer cell lines, including non-small cell lung cancer, lung and head and neck squamous cells. Cancer, breast cancer, brain cancer, bladder cancer, liver cancer, colorectal cancer, rectal cancer, colon cancer, melanocyte carcinoma, blood cancer, kidney cancer.
- It can improve blood sugar regulation and liver triglyceride accumulation.
- It also has partial anti-inflammatory effects.
- Promotes neurite outgrowth, repair and regenerate the nervous system.
- Sun Yat-sen University of Medical Research has confirmed that GMIPLUS not only can significantly inhibit cancer stem cell proliferation, invasion and metastasis, but also suppress the resistance of cancer stem cells with cisplatin. GMIPLUS is used to feed nude mice (immunized hypoxic mice) that have been previously inoculated with cancer stem cells, even Slows the rate of tumor growth.
- Blocking the IL6/Stat3 message transmission pathway is one of the mechanisms by which GMIPLUS inhibits cancer stem cells.
- Taiwan University, Yangming University, ITRI Health Center, a number of scientific research units validated!
- The CRO (commissioned research institute) completed the acute toxicity and sub-chronic toxicity tests, and obtained international authoritative patents.
The first brewer's yeast immunoregulatory protein
FIP-GMIPLUS® verified by transnational research
Among the different members of this migratory Ganoderma lucidum immunoregulatory protein family, the FIP-GMI immunomodulatory protein purified from S. cerevisiae has been researched and developed by an international team for nearly two decades. The FIP-GMI immunomodulatory protein has been confirmed In unique clinical functions of immune regulation, tumor suppression and other anti-aging, blood sugar regulation and other body-building effects. It has been recognized and protected by many globally patents, and also obtained the US Food and Drug Administration (USFDA) New Dietary Ingredients (NDI) approved.
The mechanism of action of the yeast immunoregulatory protein FIP is currently a subject of active research in the biomedical community! Based on the results of Taiwan and cross international research institutes, we found that the yeast immunomodulatory protein FIP-GMI can regulate cells containing T cells, B cells, and dendritic cells in the human body. Through the role and balance of Cellular Immunity, which in turn achieves physiological balancing and repairment.
2013
The NIH experiment in the United States found that it has inhibitory effects on variety of cancer cell lines.
2016
Obtained FDA certification and passed the highest food safety standards.
- In 2013, the National Institutes of Health (NIH) conducted experiments and found that it inhibited more than 60 cancer cell lines. So far, there have been more than 300 clinical trials and no deaths. In 2016, it was certified by the US FDA. The highest food safety standards allow users to feel more at ease and peace of mind.
- GMIPLUS® is a small molecule protein that belongs to a single side and can achieve systemic regulation and autoimmune improvement to achieve a comprehensive improvement.
- The FIP-GMI Saccharomyces cerevisiae regulatory protein has been approved by the US Food and Drug Administration (US FDA) New Dietary Ingredients (NDI) safety approval for many years of trans-Pacific multinational research.
US Food and Drug Administration NDI
Safety Certification.
GMIPLUS® Immuno Acquired multiple research patents
US Patent US7601808
US Patent US8476238
US Patent US9018171B2
US Patent US9161964B2
US Patent
US9827288B2
US9827288B2
US Patent US20160115208A1
US Patent US20160184389A1
US Patent US20190091286A1
Taiwan Patent I299735
Taiwan Patent I414307
Taiwan Patent 201625286
China Patent CN107287166A
PCT International Patent WO2016062239AI
GMIPLUS® Immuno Protein THREE functions advantages
Hsin IL, Ou CC, Wu TC, Jan MS, Wu MF, Chiu LY, Lue KH, Ko JL. GMI, an immunomodulatory protein from Ganodermamicrosporum, induces autophagy in non-small cell lung cancer cells. Autophagy. 2011;7(8):873-82.
Hsin IL, Ou CC, Wu MF, Jan MS, Hsiao YM, Lin CH, Ko JL. GMI, an Immunomodulatory Protein from Ganodermamicrosporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells.Mol Pharm. 2015;12(5):1534-43.
Chiu, L.-Y., Hu, M.-E., Yang, T.-Y., Hsin, I.-L., Ko, J.-L., Tsai, K.-J., &Sheu, G.-T. Immunomodulatory Protein from Ganodermamicrosporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells. PLoS One. 2015; 10(5): e0125774.
Hsin IL, Ou CC, Wu MF, Jan MS, Hsiao YM, Lin CH, Ko JL. GMI, an Immunomodulatory Protein from Ganodermamicrosporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells.Mol Pharm. 2015;12(5):1534-43.
Chiu, L.-Y., Hu, M.-E., Yang, T.-Y., Hsin, I.-L., Ko, J.-L., Tsai, K.-J., &Sheu, G.-T. Immunomodulatory Protein from Ganodermamicrosporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells. PLoS One. 2015; 10(5): e0125774.
Sea Buckthorn Extract
Sea Buckthorn, scientific name Hippophae rhamnoides L., is a hardy deciduous shrub native to Asia and Europe. The fruit is orange. Sea buckthorn oil is rich in vitamins, minerals, flavonoids, Omega-3, Omega-6, Omega-9 fatty acids, and the extremely rare Omega-7 fatty acids, which have rich nutritional and medical value. Because they can survive in harsh environments, they have the reputation of "the miraculous fruit in the desert."
Five Functions Of Sea Buckthorn
Contains Various Of Nutrients
Sea buckthorn is rich in fat-soluble vitamins A, D, E, K, water-soluble vitamins B1, B2, B6, B12, C, folic acid, biotin, and minerals such as potassium, calcium, magnesium, iron, and phosphorus, each of which is 100% Keyo contains 695mg of vitamin C, which is 15 times that of oranges.
Sea buckthorn oil is also one of the only plant foods to provide four omega fatty acids (omega-3, omega-6, omega-7, and omega-9). Among them, the high concentration of omega-7 palmitoleic acid helps reduce the risk factors of heart disease, reduce platelet aggregation, avoid thrombosis, stabilize blood pressure, balance cholesterol, and maintain skin health.
Omega-7 Fatty Acid—Palmitoleic Acid
1. Support heart health
Omega-7 fatty acids can prevent thrombosis and regulate the immune system, thereby reducing inflammation and protecting heart health.
2. Reduce insulin resistance
Omega-7 fatty acids help increase insulin sensitivity and promote glucose metabolism.
3. Maintain skin health
Palmitoleic acid can increase the synthesis of elastin and collagen, making the skin youthful and moisturizing.
4. Reduce inflammation and relieve dry eye discomfort
By inhibiting inflammatory cytokines, reduce inflammation in the body,and even reduce the inflammation and pain of dry eye.
5. Balancing Cholesterol
Omega-7 fat helps increase HDL (high-density lipoprotein) cholesterol and lower LDL (low-density lipoprotein) cholesterol by balancing High-sensitivity C-reactive protein(hs-crp).
In addition, sea buckthorn is also rich in antioxidant nutrients, which help protect the body against aging, heart disease, cancer, and other diseases. For example, bioflavonoids include Quercetin, Isorhamnetin, and proanthocyanidins. (Proanthocyanidins), catechins (Catechin), etc., have an extremely high antioxidant capacity to strengthen blood vessel health. In addition, Phytosterols can increase the skin barrier, protect the skin from external damage, reduce water loss, and improve skin elasticity and help wound healing.
Sea Buckthorn Extract Five functions advantages
Aronia Melanocarpa Extract
Aronia berry, scientific name Aronia melanocarpa, also known as Black chokeberry, is mainly grown in eastern North America and spread to Europe in the 18th century. They are usually used to make jam, wine, flavoring, or tea. The fruit contains high anthocyanin content. , Effectively reduce cell lipid peroxidation, thus reducing the risk of many diseases.
Wild cherry berry is the berry with the highest anthocyanidin content, the ORAC antioxidant index of the fruit is the champion, ORAC is as high as 16,062 umol TE/100g.
ORAC
Oxygen free radical absorption capacity
Oxygen radical absorbance capacity ORAC (Oxygen radical absorbance capacity) is an international unit for measuring the antioxidant capacity of different foods, namely umol TE/100g. It does achieve by combining a food sample with some molecules that generate free radical activity. Some Easily oxidized molecules are put together in a test tube to quantify the "total antioxidant capacity" of the food. The higher the value, the stronger the ability to scavenge free radicals and improve the antioxidant capacity.
Total-Oxygen free radical absorption capacity (µmol TE/100g)
The dark-colored wild cherry berries are rich in anthocyanins. Every 100 grams of fresh wild cherry berries contains up to 1480 mg of anthocyanins. Anthocyanins are bioflavonoids and have free radical scavenging and antioxidant capabilities., So it can reduce the risk of metabolic syndrome.
Total anthocyanins (mg/100g)
Aronia melanocarpa Extract Two functions advantages
Aronia berries provide antioxidants. These compounds may have cancer-fighting properties and support your heart and immune health.
Meinke, M. C., Lauer, A.-C., Haag, S. F., Darvin, M. E., Groth, N., & Lademann, J. (2012). Cutaneous radical scavenging effects of orally administered antioxidants measured by electron paramagnetic resonance spectroscopy. e-SPEN Journal, 7(4), e160–e166.
Parzonko, A., Oświt, A., Bazylko, A., & Naruszewicz, M. (2015). Anthocyans-rich Aronia melanocarpa extract possesses ability to protect endothelial progenitor cells against angiotensin II induced dysfunction. Phytomedicine, 22(14), 1238–1246. doi:10.1016/j.phymed.2015.10.009
Bräunlich, M., Slimestad, R., Wangensteen, H., Brede, C., Malterud, K., & Barsett, H. (2013). Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors. Nutrients, 5(3), 663–678.
Parzonko, A., Oświt, A., Bazylko, A., & Naruszewicz, M. (2015). Anthocyans-rich Aronia melanocarpa extract possesses ability to protect endothelial progenitor cells against angiotensin II induced dysfunction. Phytomedicine, 22(14), 1238–1246. doi:10.1016/j.phymed.2015.10.009
Bräunlich, M., Slimestad, R., Wangensteen, H., Brede, C., Malterud, K., & Barsett, H. (2013). Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors. Nutrients, 5(3), 663–678.
Bilberry Extract
Bilberry (Vaccinium myrtillus L.) is a dark blueberry also known as the European blueberry and whortleberry. The fruit is very similar to the blueberry but can be smaller, darker, and firmer. Furthermore, bilberry has much higher levels of anthocyanins.
Anthocyanins
Protection of vascular endothelium
European blueberry is one of the berries rich in anthocyanins. Every 100 grams of fresh European blueberry contains about 300-600 mg [1] of Anthocyanin glycoside. Anthocyanin can regulate the function of vascular endothelium and reduce arteries. The risk of atherosclerosis and reduce the production of inflammatory factors in the body prevent cardiovascular disease.
[1] Lätti, AK, Riihinen, KR, & Kainulainen, PS (2008). Analysis of Anthocyanin Variation in Wild Populations of Bilberry (Vaccinium myrtillus L.) in Finland. Journal of Agricultural and Food Chemistry, 56(1), 190 -196. (note below)
Improve eye fatigue
With the popularization of 3C products, people overuse their eyes, and age increases, causing free radicals in the body to rise, poor blood circulation in the capillaries around the eyes and increasing eye discomfort.
According to research, the density of fine blood vessels around the eyes is high. The anthocyanins in European blueberries maintain the integrity and elasticity of blood vessels around the eyes through antioxidant effects, promote blood circulation, relieve tension in the ciliary muscles, and reduce eye fatigue problems.
Bilberry Extract Four functions advantages
Ozawa, Y., Kawashima, M., Inoue, S., Inagaki, E., Suzuki, A., Ooe, E., … Tsubota, K. (2015). Bilberry extract supplementation for preventing eye fatigue in video display terminal workers. The Journal of Nutrition, Health & Aging, 19(5), 548–554. doi:10.1007/s12603-014-0573-6
Kosehira, M., Machida, N., & Kitaichi, N. (2020). A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial. Nutrients, 12(3), 600. doi:10.3390/nu12030600
Kosehira, M., Machida, N., & Kitaichi, N. (2020). A 12-Week-Long Intake of Bilberry Extract (Vaccinium myrtillus L.) Improved Objective Findings of Ciliary Muscle Contraction of the Eye: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial. Nutrients, 12(3), 600. doi:10.3390/nu12030600
Turmeric Extract
Turmeric Extract
A new generation of turmeric extract with all ingredients in water-dissolvable
Turmeric whose scientific name is Curcuma longa, belongs to the ginger family turmeric. Curcumin is the primary health beneficial ingredient. Turmeric tastes spicy and bitter with warm nature. This property helps blood circulation of the body. In addition, turmeric also has anti-inflammatory effects, reduces information, improves the body micro-environment, and helps to improve chronic diseases such as obesity, arthritis, cardiovascular disease, liver damage, and far more.
The rhizome of turmeric contains a variety of Curcuminoids:
Curcumin
Demethoxycurcumin, DMC
Bisdemethoxycurcumin, BDMC
GMIPLUS® Natural Elements uses a new generation of water-dispersible turmeric extract - Curcugen™ and uses the SELFD™ patented extraction method to retain the above three natural and complete ingredients.
Combining 98.5% turmeric extract and 1.5% silica (to improve fluidity) is the only raw material that does not crystallize and purify curcumin (which is easy to lose active ingredients). It retains the complete curcuminoids and their proportions, maintaining All natural ingredients strengthen the effect of water dispersion and increase absorption.
Three characteristics of Curcugen™ raw materials
Curcugen™ -Turmeric Extract advantages
- Turmeric contains biologically active compounds with powerful medicinal properties
- Curcumin is a natural anti-inflammatory compound
- Turmeric significantly improves the body's antioxidant capacity
- Curcumin promotes brain-derived neurotrophic factors, which is related to improving brain function and reducing the risk of brain diseases
- Curcumin should reduce your risk of heart disease
- Turmeric helps prevent (or even treat) cancer
- Curcumin may help prevent and treat Alzheimer's disease
- Arthritis patients respond well to curcumin supplements
- Research shows that curcumin has incredible benefits for depression
- Curcumin may help delay aging and fight age-related chronic diseases
Turmeric Extract functions advantages
CS-4™ Cordyceps sinensis Mycelium
CS-4™ Cordyceps sinensis Mycelium is selected from the companion bacterium of the larva of the Hepiali family-Paecilomyces hepiali, which is separated from the traditional Chinese medicinal material "Cordyceps," cultivated through modern fermentation, and undergoes a standardized production process and strict quality control of Cordyceps Sinensis mycelium produces fermented, fermented cordyceps with a special aroma.
The active ingredients of CS-4™ Cordyceps sinensis Mycelium
The active ingredients of CS-4™ Cordyceps sinensis Mycelium
1. Lung protection
(1) Cordycepin inhibits the NF-κB signaling pathway to prevent inflammation, activates the Nrf2 signaling pathway, reduces oxidative stress, and effectively reduces LPS-induced acute lung injury.
(2) Cordycepin inhibits the proliferation, metastasis, invasion, and cell cycle of non-small cell lung cancer (NSCLC) through phosphorylation of AMPK, promotes apoptosis and prevents the progression of NSCLC.
2. Kidney protection
(1) Cordyceps CPS-2 polysaccharides can reduce ROS generation and oxidative damage through the TGF-β1 signaling pathway, effectively improve chronic renal failure, and protect kidney function.
(2) Cordyceps CPS-F polysaccharide has antioxidant and anti-inflammatory abilities, which can inhibit the ERK1/2/Akt signaling pathway induced by platelet-derived growth factor-BB (PDGF-BB), avoid the production of ROS and inflammatory factors, and then Inhibit the proliferation of human glomerular ring cells (HMCs) and help treat glomerulonephritis.
Cordyceps sinensis Mycelium Six functions advantages
Wang, J., Teng, L., Liu, Y., Hu, W., Chen, W., Hu, X., … Wang, D. (2016). Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. J. Diabetes Res., 2016, 1–10. DOI:10.1155/2016/4368380.
Wang, J., Teng, L., Liu, Y., Hu, W., Chen, W., Hu, X., … Wang, D. (2016). Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. J. Diabetes Res., 2016, 1–10. DOI:10.1155/2016/4368380.
Wang, Y., Wang, Y., Liu, D., Wang, W., Zhao, H., Wang, M., & Yin, H. (2015). Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr. Polym., 125, 135–145. DOI:10.1016/j.carbpol.2015.02.012.
Wang, J., Teng, L., Liu, Y., Hu, W., Chen, W., Hu, X., … Wang, D. (2016). Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. J. Diabetes Res., 2016, 1–10. DOI:10.1155/2016/4368380.
Wang, Y., Wang, Y., Liu, D., Wang, W., Zhao, H., Wang, M., & Yin, H. (2015). Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr. Polym., 125, 135–145. DOI:10.1016/j.carbpol.2015.02.012.
Lei, J., Wei, Y., Song, P., Li, Y., Zhang, T., Feng, Q., & Xu, G. (2018). Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol, 818, 110–4. DOI:10.1016/j.ejphar.2017.10.029.
Wei, C., Yao, X., Jiang, Z., Wang, Y., Zhang, D., Chen, X., … Leung, E. L.-H. (2019). Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway. Pharmacol Res. DOI:10.1016/j.phrs.2019.03.011.
Wei, C., Yao, X., Jiang, Z., Wang, Y., Zhang, D., Chen, X., … Leung, E. L.-H. (2019). Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway. Pharmacol Res. DOI:10.1016/j.phrs.2019.03.011.
Wang, J., Teng, L., Liu, Y., Hu, W., Chen, W., Hu, X., … Wang, D. (2016). Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. J. Diabetes Res., 2016, 1–10. DOI:10.1155/2016/4368380.
Lei, J., Wei, Y., Song, P., Li, Y., Zhang, T., Feng, Q., & Xu, G. (2018). Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol, 818, 110–4. DOI:10.1016/j.ejphar.2017.10.029.
Wang, Y., Yin, H., Lv, X., Wang, Y., Gao, H., & Wang, M. (2010). Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis. Fitoterapia, 81(5), 397–402. DOI:10.1016/j.fitote.2009.11.008.
Wang, Y., Wang, Y., Liu, D., Wang, W., Zhao, H., Wang, M., & Yin, H. (2015). Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr. Polym., 125, 135–145. DOI:10.1016/j.carbpol.2015.02.012.
Lei, J., Wei, Y., Song, P., Li, Y., Zhang, T., Feng, Q., & Xu, G. (2018). Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol, 818, 110–4. DOI:10.1016/j.ejphar.2017.10.029.
Wang, Y., Yin, H., Lv, X., Wang, Y., Gao, H., & Wang, M. (2010). Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis. Fitoterapia, 81(5), 397–402. DOI:10.1016/j.fitote.2009.11.008.
Wang, Y., Wang, Y., Liu, D., Wang, W., Zhao, H., Wang, M., & Yin, H. (2015). Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr. Polym., 125, 135–145. DOI:10.1016/j.carbpol.2015.02.012.
Wang, J., Teng, L., Liu, Y., Hu, W., Chen, W., Hu, X., … Wang, D. (2016). Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepialiWater Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. J. Diabetes Res., 2016, 1–10. DOI:10.1155/2016/4368380.
Lei, J., Wei, Y., Song, P., Li, Y., Zhang, T., Feng, Q., & Xu, G. (2018). Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol, 818, 110–4. DOI:10.1016/j.ejphar.2017.10.029.
Wang, Y., Wang, Y., Liu, D., Wang, W., Zhao, H., Wang, M., & Yin, H. (2015). Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr. Polym., 125, 135–145. DOI:10.1016/j.carbpol.2015.02.012.
Lei, J., Wei, Y., Song, P., Li, Y., Zhang, T., Feng, Q., & Xu, G. (2018). Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol, 818, 110–4. DOI:10.1016/j.ejphar.2017.10.029.
Wang, Y., Wang, Y., Liu, D., Wang, W., Zhao, H., Wang, M., & Yin, H. (2015). Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydr. Polym., 125, 135–145. DOI:10.1016/j.carbpol.2015.02.012.
Wu, Z., Lu, J., Wang, X., Hu, B., Ye, H., Fan, J., … Zeng, X. (2014). Optimization for production of exopolysaccharides with antitumor activity in vitro from Paecilomyces hepiali. Carbohydr. Polym., 99, 226–34. DOI:10.1016/j.carbpol.2013.08.010.
Wei, C., Yao, X., Jiang, Z., Wang, Y., Zhang, D., Chen, X., … Leung, E. L.-H. (2019). Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway. Pharmacol Res. DOI:10.1016/j.phrs.2019.03.011.
Wei, C., Yao, X., Jiang, Z., Wang, Y., Zhang, D., Chen, X., … Leung, E. L.-H. (2019). Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway. Pharmacol Res. DOI:10.1016/j.phrs.2019.03.011.
Brazilian Mushroom Extract
Brazilian Mushroom, scientific name Agaricus blazei Murill, belongs to the phylum Basidiomycota of the fungus kingdom. Its umbrella is short cylindrical, light brown in color, the stalk is plump and white, and tastes almond sweet. It is native to the suburbs of Sao Paulo State, Brazil. Pineda was sent back to Japan for identification by the local Japanese in 1965 and was introduced to the Japanese market. It was widely welcomed by the Japanese people under the name "Agaricus Blazei."
Brazilian mushrooms are rich in polysaccharides, especially β-D-glucan is the most important. Studies have confirmed that Brazilian mushrooms have antioxidant and anti-inflammatory functions, help protect the gastrointestinal liver, regulate immunity, enhance anti-cancer effects, and lower blood sugar. Therefore, Brazilian mushrooms enjoy the reputation of "magic mushrooms."
Active ingredients of Brazilian mushrooms
The main effects of Brazilian Mushrooms
1. Stomach protection
The linalool extracted from Brazilian mushrooms induces apoptosis of the MKN45 gastric cancer cell line with wild-type p53 through the caspase-dependent pathway and has an anti-tumor effect.
2. Intestinal health
Brazilian mushroom extract can inhibit the message transmission of LPS receptor-TLR4, reduce the production of pro-inflammatory cytokines, chemokines, and white blood cell growth factors, have anti-inflammatory effects, and help to improve inflammatory bowel diseases.
3. Liver protection
(1) Pre-oral administration of Brazilian mushroom water extract can effectively inhibit DEN-induced hepatotoxicity and the early stage of liver cancer formation and has liver protection function.
(2) β-glucan extracted from Brazilian mushrooms can reduce phenylpyrene (B[a]P)-induced DNA damage of human liver cancer cell line HepG2. β-glucan inhibits cytochrome P450, directly binds to phenylpyrene, inhibits its entry into cells and metabolism, and captures free radicals generated during the activation of phenylpyrene to achieve liver protection.
Brazilian Mushrooms Extract Six functions advantages
Førland, D. T., Johnson, E., Saetre, L., Lyberg, T., Lygren, I., & Hetland, G. (2010). Effect of an Extract Based on the Medicinal Mushroom Agaricus blazei Murill on Expression of Cytokines and Calprotectin in Patients with Ulcerative Colitis and Crohn's disease. Scand J Immunol, 73(1), 66–75. DOI:10.1111/j.1365-3083.2010.02477.x
Hetland, G., Eide, D. M., Tangen, J. M., Haugen, M. H., Mirlashari, M. R., & Paulsen, J. E. (2016). The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. PLOS ONE, 11(12), e0167754. doi:10.1371/journal.pone.0167754.
Hetland, G., Eide, D. M., Tangen, J. M., Haugen, M. H., Mirlashari, M. R., & Paulsen, J. E. (2016). The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. PLOS ONE, 11(12), e0167754. doi:10.1371/journal.pone.0167754.
Barbisan, L. ., Miyamoto, M., Scolastici, C., Salvadori, D. M. ., Ribeiro, L. ., Eira, A. ., & de Camargo, J. L. V. (2002). Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. J. Ethnopharmacol., 83(1-2), 25–32. DOI:10.1016/s0378-8741(02)00171-x.
Angeli, J. P. F., Ribeiro, L. R., Bellini, M. F., & Mantovani, M. S. (2008). β-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2. Arch Toxicol, 83(1), 81–6. DOI:10.1007/s00204-008-0319-5.
Angeli, J. P. F., Ribeiro, L. R., Bellini, M. F., & Mantovani, M. S. (2008). β-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2. Arch Toxicol, 83(1), 81–6. DOI:10.1007/s00204-008-0319-5.
Hetland, G., Eide, D. M., Tangen, J. M., Haugen, M. H., Mirlashari, M. R., & Paulsen, J. E. (2016). The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. PLOS ONE, 11(12), e0167754. doi:10.1371/journal.pone.0167754.
Takimoto, H., Kato, H., Kaneko, M., & Kumazawa, Y. (2008). Amelioration of Skewed Th1/Th2 Balance in Tumor-Bearing and Asthma-Induced Mice by Oral Administration of Agaricus blazei Extracts. Immunopharmacol Immunotoxicol, 30(4), 747–60. DOI:10.1080/08923970802279092.
Takimoto, H., Kato, H., Kaneko, M., & Kumazawa, Y. (2008). Amelioration of Skewed Th1/Th2 Balance in Tumor-Bearing and Asthma-Induced Mice by Oral Administration of Agaricus blazei Extracts. Immunopharmacol Immunotoxicol, 30(4), 747–60. DOI:10.1080/08923970802279092.
SHIMIZU, T., KAWAI, J., OUCHI, K., KIKUCHI, H., OSIMA, Y., & HIDEMI, R. (2016). Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. Int J Oncol., 48(4), 1670–8. doi:10.3892/ijo.2016.3391.
Hetland, G., Eide, D. M., Tangen, J. M., Haugen, M. H., Mirlashari, M. R., & Paulsen, J. E. (2016). The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. PLOS ONE, 11(12), e0167754. doi:10.1371/journal.pone.0167754.
Takimoto, H., Kato, H., Kaneko, M., & Kumazawa, Y. (2008). Amelioration of Skewed Th1/Th2 Balance in Tumor-Bearing and Asthma-Induced Mice by Oral Administration of Agaricus blazei Extracts. Immunopharmacol Immunotoxicol, 30(4), 747–60. DOI:10.1080/08923970802279092.
T Takaku., Y Kimura., H Okuda. (2001). Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of Action. J Nutr., 131(5), 1409-13. DOI:10.1093/jn/131.5.1409.
Hetland, G., Eide, D. M., Tangen, J. M., Haugen, M. H., Mirlashari, M. R., & Paulsen, J. E. (2016). The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. PLOS ONE, 11(12), e0167754. doi:10.1371/journal.pone.0167754.
Takimoto, H., Kato, H., Kaneko, M., & Kumazawa, Y. (2008). Amelioration of Skewed Th1/Th2 Balance in Tumor-Bearing and Asthma-Induced Mice by Oral Administration of Agaricus blazei Extracts. Immunopharmacol Immunotoxicol, 30(4), 747–60. DOI:10.1080/08923970802279092.
T Takaku., Y Kimura., H Okuda. (2001). Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of Action. J Nutr., 131(5), 1409-13. DOI:10.1093/jn/131.5.1409.
Astragalus Extract
Astragalus is a kind of legume, mainly extracts the dried roots of Mongolian astragalus or Astragalus membranaceus as medicinal materials of traditional Chinese medicine. Astragalus is rich in polysaccharides, saponins, flavonoids, vitamins, and minerals, which can promote blood circulation, lower blood pressure, diuresis, improve renal fibrosis, lower urine protein, and immune proliferation.
The main active ingredients of Astragalus
The main effects of Astragalus
1.Cardioprotection
The flavonoids extracted from astragalus have antioxidant activity, which can inhibit LDL oxidation, reduce fatty streak on the arterial wall, reduce vascular blockage risk, promote blood circulation, and control blood pressure.
2.Kidney protection
Huangqi can prevent renal fibrosis and delay the deterioration of renal function. Huangqi inhibits the activation of renal intrinsic cells by inhibiting TGF-β, reduces the overexpression of osteopontin, reduces the infiltration and aggregation of macrophages, thereby improving renal fibrosis, and has a renal protective effect.
3.Liver protection
Astragalus polysaccharides and saponins can promote the proliferation of B cells and T cells, stimulate the activity of macrophages to improve cell phagocytosis, and have immunoproliferative effects.
Astragalus Extract Three functions advantages
Bao-Mei Shao; Wen Xu; Hui Dai; Pengfei Tu; Zhongjun Li; Xiao-Ming Gao (2004). A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun, 320(4), 1103-11. doi:10.1016/j.bbrc.2004.06.065.
Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 4th ed. Sydney: Churchill Livingstone Elsevier, 2015.
Braun L, Cohen M. Herbs and natural supplements: an evidence-based guide, 4th ed. Sydney: Churchill Livingstone Elsevier, 2015.
Glutathione
Glutathione is a tripeptide composed of Glutamate, Cysteine , and Glycine. The body can synthesize by itself and coexist in each cell, especially There is a high concentration of glutathione in the liver.
The function of Glutathione
1.Antioxidant
The cysteine residue in glutathione contains a sulfhydryl group (-SH), which is a functional group involved in the redox reaction in the body, which makes glutathione possess antioxidant activity by directly neutralizing free radicals, or It is used as a cofactor of antioxidant enzymes to scavenge free radicals, reduce oxidative stress and damage, and regulate the redox homeostasis in cells. It is the highest concentration of antioxidants in cells.
At the same time, glutathione is also an important hub of the entire antioxidant system, which can promote the regeneration of antioxidants such as vitamin C and E. It can play an antioxidant multiplier effect, eliminate free radicals, and effectively terminate the chain caused by free radicals. Locking reaction, so it has the reputation of "the mother of anti-oxidation of the human body."
2.Assist the liver's detoxification function
The liver is the most important detoxification organ of the human body. The toxins or their metabolites in the body will react with the sulfhydryl groups on the glutathione in the liver to form a more hydrophilic conjugated body. Toxins are soluble in water and easily excreted from the body to play a detoxification effect.
3.Promote fat metabolism
PGC-1α is a transcriptional activation cofactor expressed in skeletal muscle, mainly involved in mitochondrial synthesis and regulation of mitochondrial function. During exercise, glutathione can promote the performance of PGC-1α in skeletal muscle, increase mitochondrial biosynthesis, increase fatty acid oxidation, and improve the decline of pH in the body, thus reducing muscle fatigue caused by exercise.
With aging, life pressure, lack of whole-grain fruits and vegetables, excessive tobacco and alcohol, excessive exercise, and excessive exposure to ultraviolet rays, toxins, and environmental pollution, the body's glutathione content will decrease rapidly, causing the body to produce a large number of free radicals and increase oxidative stress. It causes damage and increases the risk of aging, liver disease, cardiovascular disease, degenerative neurological disease, and cancer.
Glutathione
OPITAC® Glutathione is manufactured by specially selected non-based modified edible torula yeast fermented. It produces 98% high-purity natural reduced glutathione (GSH), the world's largest, most historical, highest quality, and The only glutathione obtained the US FDA-GRAS food safety certification.
Glutathione raw material advantage
Production of non-based modified edible round yeast ferment
Complete absorption and utilization characteristics
Many international scientific documents confirm that OPITAC® glutathione can be fully absorbed and utilized and significantly increase the body's glutathione content.
1.A Japanese study in the 2014 "Journal of Agricultural and Food Chemistry" pointed out:
The reduced GSH derived from the yeast can be completely transported into the body through the intestinal epithelial cells and quickly metabolized into oxidized GSSG, stored in the red blood cells and liver, and significantly increases the glutathione content body.
Kovacs-Nolan, J., Rupa, P., Matsui, T., Tanaka, M., Konishi, T., Sauchi, Y., … Mine, Y. (2014). In Vitro and ex Vivo Uptake of Glutathione (GSH) across the Intestinal Epithelium and Fate of Oral GSH after in Vivo Supplementation. J Agric Food Chem, 62(39), 9499–506. DOI：10.1021/jf503257w.
2.The Japanese study in the 2014 "Journal of Agricultural and Food Chemistry" pointed out:
After taking 50 mg glutathione per kilogram weight orally of Healthy subjects, we can observe that the white matter-bound GSH content in their blood increases significantly with in 60-120 minutes after ingestion.
Park, E. Y., Shimura, N., Konishi, T., Sauchi, Y., Wada, S., Aoi, W., … Sato, K. (2014). Increase in the Protein-Bound Form of Glutathione in Human Blood after the Oral Administration of Glutathione. J Agric Food Chem, 62(26), 6183-9. DOI：10.1021/jf501338z.
Acquired multiple International Patents and Certifications
特開平8-325144
特開平10-191963
特開平6-56884
特開平5-276895
特開2003-24011
特開2004-51534
特開2004-283125
特開2007-55962
特開2007-254324
特開2007-254325
特開2009-51768
昭64-63342
昭63-68096
昭59-151894
昭52-125687
昭62-292797
EP 0797929 A1
US 5968810
Glutathione Three functions advantages
Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., … Nakajima, A. (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC Gastroenterol, 17(1). DOI:10.1186/s12876-017-0652-3.
Cristovao, F.L., Manuel, F-F., Cristina, P-W. (2006). Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci, 79(21), 2056-68. DOI: 10.1016/j.lfs.2006.06.042.
Cristovao, F.L., Manuel, F-F., Cristina, P-W. (2006). Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci, 79(21), 2056-68. DOI: 10.1016/j.lfs.2006.06.042.
Algae Oil Powder
Algae Oil Powder
Algae is the bottom producer of the marine food chain. It can synthesize Omega-3 polyunsaturated fatty acids by itself, so it has the reputation of "vegetarian fish oil," It is also the most direct way to supplement Omega-3 polyunsaturated fatty acids. Compared with ordinary algae that only contain DHA, Schizochytrium sp. is rich in Omega-3 polyunsaturated fatty acids, among which DHA (Docosahexaenoic acid) and EPA (Eicasapentaenoic acid) are the most biologically active. Therefore, it is a good plant source of Omega-3 (EPA+DHA).
Studies have confirmed that: Omega-3 fatty acids (EPA+DHA) are beneficial to the brain, vision care, cognitive function improvement, cardiovascularprotection, lowering blood lipids, and immune regulation.
Docosahexaenic Acid (DHA) is the main component of cell membranes. It can enter brain cells and photoreceptor cells through the blood-brain barrier and blood-retinal barrier, respectively, to form the gray matter of the brain and the retina of the eye, and help maintain its normal nerve function. Therefore, DHA can help children's vision and brain development. For adults, it can maintain its function and slow down the deterioration of vision and memory, learning, mood, and other cognitive abilities.
Eicosapentaenoic acid (EPA) is an Omega-3 fatty acid, which can lower blood cholesterol and triglycerides, improve blood pressure, inhibit platelet aggregation and reduce thrombosis, so it is called "vascular scavenger" and can prevent cardiovascular disease.
In addition, both EPA and DHA have anti-inflammatory effects, which can inhibit the metabolism of arachidonic acid, thereby reducing the production of pro-inflammatory hormones, inhibiting inflammation, and exerting an immunomodulatory effect.
Algae Oil Powder
Algameg-3™ algae oil powder is selected from Schizochytrium sp., fermented in a closed system, deodorized and purified by multiple refining procedures, and then adopts the exclusive multi-layer micro-embedded oil seal powder technology (Multi-layer Microencapsulation PUFA-Sealing Technology) made. PUFA-Sealing™ oil-sealing powder-making technology uses multi-layer micro-embedding methods to make oil droplets into powder, and the powder can be evenly dispersed in an aqueous solution. Therefore,Algameg-3™ algae oil powder is stable and not easy to oxidize and deteriorate, has no algae smell, has a long validity period, is highly water-soluble, and has no doubts about organic solvents heavy metals, and microbial contamination. It is a high-quality plant source, Omega-3.
The main active ingredients of algae oil powder
The main effects of algae oil powder
1. Inhibit brain nerve damage
(1) Omega-3 (EPA+DHA) can inhibit the expression of pro-inflammatory cytokines in the hippocampal gyrus, promote the activation of c-Fos protein-related nerve cells, reduce nerve inflammation, and improve age-related spatial memory impairment.
(2) DHA has a protective effect on the cognitive function of Alzheimer's disease gene transgenic mice Tg2576. DHA can inhibit the cleavage of amyloid precursor protein (APP) by secretory enzymes, thereby reducing the production of β-amyloid (Aβ), and reducing the deposition of Aβ to form plaques, thus reducing the cognitive function degradation caused by brain nerve cell necrosis.
(3) DHA helps slow down the cognitive decline (ARCD) caused by aging, including visuospatial learning and episodic memory.
2. Promote cranial nerve repair
(1) Omega-3 fatty acids can improve cognitive impairment caused by traumatic brain injury (TBI). Omega-3 fatty acids can inhibit the accumulation of oxidative stress caused by TBI, avoid brain-derived neurotrophic factor (BDNF) and its downstream regulation of synaptic plasticity synapsin I (synapsin I) and cyclic adenylate monophosphate response element-binding The reduction of protein (CREB) in turn reduces the disability of nerve synapses. It achieves the purpose of protecting learning ability.
(2) Omega-3 fatty acids can be used as an antidepressant-Citalopram (Augmentation) to improve the signs and symptoms of depression effectively.
(3) EPA/DHA can prevent and relieve neuropathic pain caused by peripheral nerve injury. EPA/DHA can inhibit tumor necrosis factor (TNF) production in the spinal cord and reduce the migration of neutrophils, thereby inhibiting nerve inflammation and slowing down pain hypersensitivity. It can also stimulate remyelination and promote nerve function restoration.
algae oil powder won some international certifications
Algameg-3™ Two functions advantages
Labrousse, Virginie F.; Nadjar, Agnès; Joffre, Corinne; Costes, Laurence; Aubert, Agnès; Grégoire, Stéphane; Bretillon, Lionel; Layé, Sophie; Schunck, Wolf-Hagen (2012). Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice. PLoS ONE, 7(5), e36861. doi:10.1371/journal.pone.0036861.
Yurko-Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A., … Stedman, M. (2010). Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement, 6(6), 456–64. doi:10.1016/j.jalz.2010.01.013.
Lim, G. P. (2005). A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model. J Neurosci, 25(12), 3032–40. doi:10.1523/jneurosci.4225-04.2005.
Yurko-Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A., … Stedman, M. (2010). Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement, 6(6), 456–64. doi:10.1016/j.jalz.2010.01.013.
Lim, G. P. (2005). A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model. J Neurosci, 25(12), 3032–40. doi:10.1523/jneurosci.4225-04.2005.
Wu, A., Ying, Z., & Gomez-Pinilla, F. (2004). Dietary Omega-3 Fatty Acids Normalize BDNF Levels, Reduce Oxidative Damage, and Counteract Learning Disability after Traumatic Brain Injury in Rats. J Neurotrauma, 21(10), 1457–67. doi:10.1089/neu.2004.21.1457.
Gertsik, Lev; Poland, Russell E.; Bresee, Catherine; Rapaport, Mark Hyman (2012). Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder. J Clin Psychopharmacol, 32(1), 61–4. doi:10.1097/JCP.0b013e31823f3b5f.
Silva, Rafaela V.; Oliveira, Julia T.; Santos, Bruna L. R.; Dias, Fabiana C.; Martinez, Ana M. B.; Lima, Cleverton K. F.; Miranda, Ana L. P. (2017). Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice. Front Pharmacol, 8, 723. doi:10.3389/fphar.2017.00723.
Gertsik, Lev; Poland, Russell E.; Bresee, Catherine; Rapaport, Mark Hyman (2012). Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder. J Clin Psychopharmacol, 32(1), 61–4. doi:10.1097/JCP.0b013e31823f3b5f.
Silva, Rafaela V.; Oliveira, Julia T.; Santos, Bruna L. R.; Dias, Fabiana C.; Martinez, Ana M. B.; Lima, Cleverton K. F.; Miranda, Ana L. P. (2017). Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice. Front Pharmacol, 8, 723. doi:10.3389/fphar.2017.00723.
30 Billion Probiotics
In the case of physical discomfort, chronic diseases, and even cancer, it often happens that you can't eat or have a bowel movement, causing malnutrition, unable to maintain the body's resistance and daily activities, and quickly lead to poor treatment results.
Therefore, GMIPLUS® natural elements are added with 30 billion probiotics, combined with high-quality prebiotics-berries, to reorganize the ecological balance of the intestinal flora and strengthen the intestinal nutrient absorption capacity. The balance of good bacteria and harmful bacteria helps Reduce allergic reactions, assist intestinal digestion, promote intestinal peristalsis, and prevent constipation.
Clinically, when cancer patients posted chemotherapy and radiotherapy, due to the increase of pro-inflammatory hormones, the apoptosis of intestinal epithelial cells leads to damage, bacteria are unable to colonize, diarrhea and mucositis occur, and the patients Eating conditions are prone to malnutrition problems. The clinical application of probiotics shows that probiotic strains can reduce the incidence of postoperative inflammation in cancer patients.
Four significant effects of 30 billion probiotics
30 Billion Probiotics functions advantages
Mahmoud A. M., Anne M., John S., Laila H., Plasma cobalamin and folate and their metabolic markers methylmalonic acid and total homocysteine among Egyptian children before and after nutritional supplementation with the probiotic bacteria Lactobacillus acidophilus in yoghurt matrix. Int J Food Sci Nutr. (2006);57(7-8):470-80.
Yeung, C.-Y., Chan, W.-T., Jiang, C.-B., Cheng, M.-L., Liu, C.-Y., Chang, S.-W., … Lee, H.-C. (2015). Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model. PLOS ONE, 10(9), e0138746.
Yeung, C.-Y., Chan, W.-T., Jiang, C.-B., Cheng, M.-L., Liu, C.-Y., Chang, S.-W., … Lee, H.-C. (2015). Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model. PLOS ONE, 10(9), e0138746.
IMMUNITY BALANCING
Precision Healthcare Functional supplement, Q&A
Q：How do I take MEDBRING GMIPlUS® IMMUNITY BALANCING?
It is recommended to take 2 capsules a day for daily maintenance. It is suitable before and after meals. It can be taken in separate meals and served with cold and warm water. For degenerative diseases, immune system imbalance, metabolic disorders, or aging, the recommended dosage is 4 capsules a day. In addition, for cancer patients, you can take 6 capsules daily or more, or according to the doctor's instructions.
※It is recommended to take it after consulting a professional medical physician for instructions.
Q：Who is suitable to take MEDBRING GMIPlUS® IMMUNITY BALANCING?
GMIPlUS® IMMUNITY BALANCING are suitable for people who want to balance immunity, regulate physiological functions, promote metabolism, and adjust physical fitness.
Q：Who should pay attention to using MEDBRING GMIPlUS® IMMUNITY BALANCING?
This product contains glutathione. Those who are allergic to protein should avoid taking it. In addition, pregnant women, breastfeeding women, and children over 6 years old, please consult a professional medical physician for instructions.
Q：Is it suitable to take GMIPlUS® IMMUNITY BALANCING for those who are taking the medication regularly?
The algae oil powder in this product contains Omega-3, which has an anticoagulant effect. Therefore, people with abnormal blood coagulation function may increase the anticoagulant effect. If you want to consume GMIPlUS® IMMUNITY BALANCING, please consult a professional medical physician for instructions.
Q：What are the comparative advantages of MEDBRING GMIPlUS® IMMUNITY BALANCING and products on the market?
This product integrates eleven key formulas for physical fitness adjustment, which can effectively maintain healthy body tissues and normal metabolism. It can also balance immunity, increase antioxidant effects, and balance the physiological functions of various human systems to achieve a comprehensive health protection.
Q：What are the advantages of MEDBRING GMIPlUS® IMMUNITY BALANCING compared with general commercial immunomodulatory products?
The water-dispersible turmeric extract in GMIPlUS® IMMUNITY BALANCING uses SELFD™ patented technology and 1.5% silicon dioxide combination to extract all the ingredients and proportions of turmeric completely, the content is as high as 98.5%, and it strengthens the water dispersion effect and increases bioavailability.
Glutathione is made of high-purity reduced glutathione produced by a major Japanese factory, with a content of 98%, and is made from non-based modified edible round yeast ferment. Studies have confirmed that it has anti-oxidation and liver protection effects and can be completely absorbed and utilized by the human body. It has obtained 31 international certifications and patents on safety, religion, raw materials, and quality, ensuring the safety and quality of raw materials.
Q：What is the source of MEDBRING GMIPlUS® IMMUNITY BALANCING?
The exclusive patented GMI-Immuno protein (GMI immunomodulatory protein) in GMIPlUS® IMMUNITY BALANCING is derived from the cultivation of Saccharomyces cerevisiae through precision genetic medicine. It has multiple immune regulation and anti-cancer effects and can inhibit a variety of cancer cells. Effect.
Precision medical functional supplements.
MEDBRING adheres to
the principle of professional responsibility and to uses the exclusive patented extraction from natural sources in the selection of ingredients to ensure the efficacy of the products.
Integrate the precision
only select the process with international GMP, HACCP, ISO certification laboratories of health food factories, and the production process is strictly monitored to ensure product quality.
Established
teams of a multi-national professional physician, nutritionist, pharmacist R&D laboratory to lead the development and production of high-quality functional medical supplements in the world.
Insist on the use
of ingredients that have obtained internationally relevant certifications, and the original suppliers have repeatedly tested in the laboratory or clinical to ensure that the source of ingredients is absolutely free from pollution.
Safe and secure!
The functional medical supplements series had passed a number of organic and related food certifications.
Australian
Certified Organic
Halal
Certification
Kosher Meat
Certification
ISO
9001:2000
HACCP
Quality meets the three highest international standards of FDA, EP, TGA.
(FDA Food and Drug Administration)｜(EP EU)｜ (TGA Australian Drug Administration)
Adheres to the profession. Pursuit of quality.
Rigorous attitude worthy of your trust!
Precision health supplements
Tailored health solutions
Contact us
USA：MedicLink USA Inc.
13021 Arctic Circle, Santa Fe Springs, CA 90670, USA
USA：1714-323-7135
Mail：service@medic-link.com